NextGen PGx

GLP-1 & Peptide Pharmacogenomics

What does your DNA say about your GLP-1?

Research connecting GLP1R, GIPR, and related genes to GLP-1 medication response is still emerging. This panel reports those variants alongside well-established medication-metabolism genes like CYP2D6 and CYP2C19 — results that may provide insights for conversations with your prescriber. They cannot predict whether a GLP-1 will work for you.

GIPRGLP1RCYP2D6CYP2C19CYP2C9SLCO1B1+ 30 more
Order Your Kit — $489 See the five key genes$489 one-time  ·  no subscription
Certified clinical laboratoryClinician-reviewedCPIC-alignedResults for life
Important: Genetic research into GLP-1 and peptide medication response is still emerging, and no genetic test can predict whether a specific medication will work for you, how much weight you will lose, or which side effects you may experience. PGx results are decision-support information for a qualified healthcare provider — never a substitute for medical advice. Do not start, stop, or change any medication based on these results alone.

Why this matters on a GLP-1

1.8×

higher chance of moderate-to-severe vomiting on tirzepatide for people carrying one GIPR variant — the clearest drug-specific genetic finding in the field.

GIPR rs1800437. Tirzepatide only, not semaglutide.
1 in 3

GLP-1 users needed support for a gut symptom within the first year — and that support arrives as another prescription.

31.9% GI adverse events. Matched cohort, 329,974 patients. Dig Dis Sci, 2026.
300+

medications your report covers, across gut, heart, pain and mental health. One swab answers for every one of them.

NextGen PGx Complete PGx Test.

Where the difference comes from

Two people. Same medicine. Completely different experience.

One sails through titration. The other spends three weeks nauseated and wondering what they're doing wrong. Same drug, same dose, same effort — and the reason sits in two places, both of them genetic.

First, the receptors. GLP-1 medicines work by plugging into receptors on your cells. Semaglutide reaches one of them. Tirzepatide reaches two. The genes that build those receptors — GLP1R and GIPR — carry common variants, and those variants have been linked to real, measured differences in how people experience the medicine.

Second, everything prescribed alongside. The anti-sickness tablet. The reflux tablet. The painkiller. The statin. Each is switched on and off by an enzyme, and the genes behind those enzymes are the best-evidenced in all of clinical pharmacology.

The most personalised part of your protocol has been the one thing left to chance.

How a GLP-1 medicine reaches your cells

Semaglutide
Ozempic · Wegovy
GLP1R

The receptor every GLP-1 medicine plugs into. Variant linked to modestly more weight loss.

Tirzepatide
Mounjaro · Zepbound
GIPR

The second receptor — reached by tirzepatide only. Variant linked to 1.8× more moderate-severe vomiting.

Your cell surface

The five that matter most

Five genes that shape your GLP-1 experience

Two sit inside the receptors your medicine was designed to reach. Three decide whether the medicines given alongside it will actually work. Your report covers all five — and more than thirty markers besides.

1.8×GIPR

The second receptor — and the clearest finding in the field

Tirzepatide works on two receptors, not one. This variant partly disables the second, and carriers are around 1.8 times more likely to experience moderate-to-severe vomiting — on tirzepatide specifically, not on semaglutide. It is the strongest, cleanest drug-specific genetic finding in GLP-1 medicine, and it is the kind of thing worth knowing before the first dose rather than during the third week.

Relates to: tirzepatide · Mounjaro · Zepbound
GLP1R

The receptor every GLP-1 plugs into

GLP1R builds the receptor that semaglutide, tirzepatide and liraglutide were all designed to reach. A common variant here has been linked to modestly more weight loss — around 0.76 kg extra per copy carried. A small effect, measured in large studies, and reported at exactly that size.

Relates to: semaglutide · tirzepatide · liraglutide
CYP2D6

The enzyme behind your anti-sickness tablet

CYP2D6 switches off ondansetron — the tablet most often given for GLP-1 nausea. Ultra-fast processors clear it before it has a chance to work; slow processors are at risk from codeine and tramadol. It carries the highest co-prescription probability on the panel, and its prescribing guideline was refreshed by CPIC in April 2026.

Relates to: ondansetron · metoclopramide · codeine · tramadol · several antidepressants
CYP2C19

The enzyme behind your reflux tablet

GLP-1 medicines slow the stomach, so heartburn is common and acid-reducing tablets are heavily prescribed — around two in ten users within a year. This enzyme decides how well they work, and it also governs clopidogrel and several antidepressants.

Relates to: omeprazole · pantoprazole · lansoprazole · sertraline · escitalopram
CYP2C9

The enzyme behind everyday painkillers

Slow processors reach higher drug levels on standard doses of ibuprofen, meloxicam and celecoxib, which raises the risk of stomach and kidney strain. Three of these six markers are common in people of African ancestry — a cheaper two-marker panel would quietly give them the wrong answer, so we carry the full set.

Relates to: ibuprofen · meloxicam · celecoxib · piroxicam

Evidence A — established by very large studies and repeated independently, or written into an official prescribing guideline. Evidence B — good evidence, repeated, but smaller or from a single well-run study, and reported with that caveat attached. Nothing below grade B appears on this panel.

Knowing before the first dose beats finding out in week three.

Titration is where most people quit. A slower, planned dose build-up — decided in advance rather than as a reaction to feeling terrible — is exactly the kind of decision a genetic result can inform.

How a result reads

You sit somewhere on a spectrum. Your report says where.

Take CYP2D6 — the enzyme behind the anti-sickness tablet. There are five recognised positions, and where you sit changes what your prescriber would choose.

CYP2D6 metaboliser spectrum

POOR
Drug builds up. Standard dose may be too much.
INTERMEDIATE
Slower than average clearance.
NORMAL
Standard dosing expected to suit you.
RAPID
Faster clearance — less effect from the usual dose.
ULTRARAPID
Cleared before it works. The tablet may simply fail.

Your report states your position for every gene on the panel, in exactly these words.

And the rest of your medicine cabinet

The five genes above are the headline. Your report goes considerably further.

MedicineGeneWhat your result speaks to
Statinssimvastatin · atorvastatin · rosuvastatinSLCO1B1How much statin reaches the liver rather than the bloodstream. Carriers are more prone to muscle aches — genuinely confusing alongside a GLP-1, and worth being able to tell apart.
Rosuvastatina very commonly prescribed statinABCG2Guideline-level dosing advice on one of the most-prescribed statins in the country.
High-dose vitamin C infusionsalso certain antimalarialsG6PDIn people with G6PD deficiency, a high-dose IV vitamin C infusion can destroy red blood cells. IV vitamin therapy is standard inventory at many wellness clinics — this is the marker most able to prevent an acute hospital admission.
Bupropion & sertralinebupropion is half of naltrexone-bupropionCYP2B6Bupropion also blocks CYP2D6 — so anyone taking it effectively becomes a slower processor of the anti-sickness tablet. Your report applies that rule automatically.
Certain hospital antibioticsgentamicin · amikacin · tobramycinMT-RNR1In carriers, a single dose of these IV antibiotics can cause permanent deafness. Tested once, costs nothing extra, and prevents an irreversible harm.
Iron tablets and iron infusionsa routine response to "I'm tired"HFEIdentifies people who already store too much iron, for whom more causes liver and joint damage over time. A cheap way to avoid a common, avoidable mistake.

Peptides, hormones & longevity protocols

You optimise everything else. This is the missing input.

You track your sleep. You know your labs. You chose your clinic carefully and you ask better questions than most physicians expect. Somehow, the one variable nobody has measured is the one that decides how your body handles medication.

A serious protocol is never just the peptide. It is the anti-inflammatory after training. The reflux tablet. The statin. The IV vitamin drip. The antidepressant you have been on for years. Every one of those runs through enzymes your DNA already determined — and your report reads them.

It is the same logic you already apply to everything else you optimise: measure first, then decide. This is simply the measurement nobody offered you until now.

Illustration of three injection vials beside a simple molecular chain.

What arrives in your portal

Clarity you can hand straight to your provider

Not a wall of raw data. A clear, readable report built to be useful inside a seven-minute appointment.

Your position on every gene

Poor, intermediate, normal, rapid or ultrarapid — stated in plain language for each enzyme, with what that tends to mean.

Guidance across 300+ medicines

Organised by therapeutic area, so you can find the one you were prescribed this morning in seconds.

A one-page prescriber summary

Every recommendation carries its guideline, strength and citation, so your provider can verify the basis rather than take our word for it.

Yours for life

Your genotype is permanent. Your report is dated and versioned, so you always know which edition of the guidance you are reading.

Illustration: a cheek swab and collection tube connected by a DNA strand to a tablet showing a pharmacogenomic report.
Illustration of a woman in profile with a DNA double helix drawn behind her.

Who this is for

People who take this as seriously as you do

  • You are about to start, or about to step up a dose. Knowing how you handle tirzepatide's second receptor — and the supporting medications — is worth far more before than during.
  • You are on a GLP-1 and the side effects are wearing you down. Nausea that won't settle, reflux that started with the shot, a tablet that barely takes the edge off.
  • You run peptides, hormones or a longevity protocol at a med spa or wellness centre, and you measure before you commit.
  • You already take other prescriptions. A statin, an SSRI, something for pain. This is where pharmacogenomics has always earned its keep.
  • You want an answer that comes from your own biology — and stays true for the rest of your life.

How it works

Two minutes at your kitchen table

No blood draw. No clinic visit. No fasting. No subscription. One swab, one time, and the answer is yours permanently.

Step 1 — Order

Your kit ships straight away

You receive your Patient ID, Order ID and Kit ID the moment you check out. Shipping is prepaid and tracked both ways.

Step 2 — Swab

Scan, swab, post

Activate with the QR code, run the swab inside your cheek, drop it in the mail in the prepaid envelope. That is the whole procedure.

Step 3 — Results

Certified lab, clinician-reviewed

Processed by a certified clinical laboratory, reviewed by a clinician, released to your secure portal with a prescriber-ready summary.

Why NextGen PGx

Built to the standard of a clinical laboratory

Certified clinical laboratory

Analysed in an appropriately certified clinical laboratory — not a consumer sequencing service.

Clinician-reviewed

Every report is professionally reviewed before release. Nothing reaches you unchecked.

Graded evidence on every marker

Each result carries an A or B evidence grade. Nothing below grade B is on the panel.

The full marker set, not the cheap one

Six CYP2C9 markers, not two. Ancestry-complete panels, because a shorter panel gives some people the wrong answer.

Your data is never sold

Encrypted, role-restricted access. We do not sell genetic data — to anyone, at any price.

One price, no subscription

$489 once. No renewal, no upsell tier, no annual fee to keep reading your own results.

A row of modern DNA genotyping instruments and a rack of clear sample tubes in a bright clinical genomics laboratory.

The maths

Trial and error is the expensive option

Every medication that doesn't work has a price. The prescription. The follow-up appointment. The weeks you spent feeling unwell waiting to find out. The month of progress lost because the side effects made you skip a dose.

Your genotype costs $489 once, and you never pay for it again.

A GLP-1 program, per year$6,000 – $15,000
A medication that doesn't suit youweeks lost
Repeat visits to sort it outtime + copays
Doing it again next yearthe same again
Knowing, once, for life$489
FAQ

The things people ask before they order

Questions about pharmacogenomic testing, GLP-1 medications and what your report covers.

Important Medical Disclaimer

NextGen PGx testing is intended to provide genetic information that may support discussions with qualified healthcare professionals. It is not intended to diagnose, treat, cure, or prevent any disease and does not guarantee medication safety, effectiveness, tolerability, or weight-loss outcomes.

The clinical relevance of pharmacogenomic findings varies by gene, medication, patient, and strength of available evidence. Certain associations involving GLP-1 receptor agonists and peptide-based therapies may be emerging or investigational and may not be included in FDA-approved drug labeling or established pharmacogenomic prescribing guidelines.

Never start, stop, substitute, or change the dosage of any medication based solely on a genetic test. All treatment decisions must be made by a qualified healthcare professional after reviewing the patient's complete clinical information. If you experience severe or concerning symptoms, seek prompt medical attention.

Read our Privacy Policy and Notice of Privacy Practices for complete details.

Important: Pharmacogenomic (PGx) testing provides information about how genetic variations may influence an individual's response to certain medications. Results are intended to support, not replace, the judgment of a qualified healthcare professional and should not be used to diagnose, treat, cure, or prevent any disease. Do not start, stop, change, or adjust any medication based solely on PGx test results. Always consult your physician, pharmacist, or other qualified healthcare provider before making medication or treatment decisions. PGx results do not guarantee that a medication will be effective, ineffective, or free from side effects.

One swab. One time. Answers for life.

GIPR. GLP1R. CYP2D6. CYP2C19. CYP2C9 — and thirty more markers, read once, kept for good.

Order Your Kit — $489Talk to our team
Certified clinical laboratoryClinician-reviewedPrepaid shipping both waysNo subscription

Related Resources

GLP-1 Genetic TestingSemaglutide Genetic TestingTirzepatide Genetic TestingWeight Loss Medication Genetic Test